Global coagulation assays in hemophilia A: A comparison to conventional assays

Specific and global coagulation assays in the diagnosis of discrepant mild hemophilia A.

The activity of the factor VIII coagulation protein can be measured by three methods: a one or two-stage clotting assay and a chromogenic assay. The factor VIII activity of most individuals with mild hemophilia A is the same regardless of which method is employed. However, approximately 30% of patients show marked discrepancies in factor VIII activity measured with the different methods. The ob...

Coagulation assays.

Case 1: Mr F, a 75-year-old man with diabetes, was admitted with non–ST-segment-elevation acute coronary syndrome. In addition to other medications, he is receiving 1 mg/kg enoxaparin every 12 hours. He is scheduled for cardiac catheterization later in the afternoon. Earlier this morning, his activated partial thromboplastin time (aPTT) was 30 seconds. How should his anticoagulants be managed? ...

Prenatal diagnosis of classic hemophilia (hemophilia A) by immunoradiometric assays.

During the period from 1978 to 1983, 92 pregnancies have been evaluated by fetoscopy for the prenatal diagnosis of hemophilia A. Satisfactory fetal plasma samples were obtained in 80 instances and the diagnosis--or exclusion--of hemophilia was made by immunoradiometric assay of the factor VIII coagulant protein (VIII:CAg). The accuracy of the diagnosis established by fetoscopy has been verified...

HER2 Testing in Invasive Breast Cancer: a Comparison between Immunohistochemistry and FISH Assays

A Review on Angiogenesis and Its Assays

Angiogenesis or formation of new blood vessels from preexisting vasculature is a key process in some physiological conditions such as wound healing, growth, and action of female reproductive organs. Moreover, disturbance of the mechanisms of physiological angiogenesis has a role in pathogenesis of some diseases in the form of overproliferation of blood vessels such as cancers, psoriasis, arthri...